Odds stacked against Steelers heading into game vs. 49ers

San Francisco 49ers running back Matt Breida (22) runs the ball during the first half an NFL football game against the Cincinnati Bengals, Sunday, Sept. 15, 2019, in Cincinnati. (AP Photo/Gary Landers)

Pittsburgh Steelers newly acquired safety Minkah Fitzpatrick smiles as he warms up during an NFL football practice, Wednesday, Sept. 18, 2019, in Pittsburgh. (AP Photo/Keith Srakocic)

Pittsburgh Steelers quarterback Ben Roethlisberger looks at the scoreboard as he walks off the field as time runs out in a loss to the Seattle Seahawks in an NFL football game in Pittsburgh, Sunday, Sept. 15, 2019. Roethlisberger did not play the second half of the game. (AP Photo/Gene J. Puskar)

San Francisco 49ers running back Raheem Mostert (31) celebrates his touchdown during the first half an NFL football game against the Cincinnati Bengals, Sunday, Sept. 15, 2019, in Cincinnati. (AP Photo/Frank Victores)

Pittsburgh Steelers quarterback Mason Rudolph (2) passes over Seattle Seahawks nose tackle Bryan Mone (79) in the second half of an NFL football game Sunday, Sept. 15, 2019, in Pittsburgh. (AP Photo/Don Wright)