Rams, 49ers head into 1st meeting off tough losses

Los Angeles Rams quarterback Matthew Stafford reacts after injuring his ankle while throwing an incomplete pass during the second half of an NFL football game against the Tennessee Titans, Sunday, Nov. 7, 2021, in Inglewood, Calif. (AP Photo/Ashley Landis)

Los Angeles Rams wide receiver Van Jefferson can't make the catch as Tennessee Titans safety Amani Hooker defends during the second half of an NFL football game Sunday, Nov. 7, 2021, in Inglewood, Calif. (AP Photo/Marcio Jose Sanchez)

Los Angeles Rams head coach Sean McVay looks on during the second half of an NFL football game against the Tennessee Titans. Sunday, Nov. 7, 2021, in Inglewood, Calif. (AP Photo/Marcio Jose Sanchez)

San Francisco 49ers quarterback Jimmy Garoppolo (10) walks off the field after the 49ers were defeated by the Arizona Cardinals in an NFL football game in Santa Clara, Calif., Sunday, Nov. 7, 2021. (AP Photo/Jed Jacobsohn)

San Francisco 49ers wide receiver Deebo Samuel sits on the bench during the second half of an NFL football game against the Arizona Cardinals in Santa Clara, Calif., Sunday, Nov. 7, 2021. (AP Photo/Tony Avelar)